Engineering a Technology Platform for Organoids

Non-destructive surface acoustic wave sensing for real-time material characterisation of GelMA hydrogels

MEM Stamp, M Halwes, LC Aguilar, K Callaghan, D Nisbet, DJ Collins

2026-07-01

Gelatin Methacryloyl (GelMA) hydrogels are widely utilized in biomedical applications due to their biocompatibility and tenable me..

Renovating Neural Networks With Viral-Mediated Gene Transfer From A Tissue Contacting Matrix Mimic

SS Dehnavi, N Mahmoudi, Y Wang, S Cheeseman, R Ferreira, RD Hannan, L Lisowski, VSJ Craig, N Moriarty, CL Parish, RJ Williams, DR Nisbet

2026-03-20

Neurodegenerative diseases such as Huntington's Disease (HD) have a significant impact on healthcare accessibility and costs. A fa..

The Importance of Sex-Based Comparisons in Preclinical Nanomedicine and Regenerative Chronic Wound Therapies

N Mahmoudi, MH Saeed, L Peereboom, X Liu, DR Nisbet, M Mahmoudi

2025-10-13

It is increasingly recognized that immune responses, plasma proteomes, and various biosystem reactions to advanced therapeutics, s..

Tuneable Hydrogel Porosity via Dynamic Tailoring of Spinodal Decomposition

M Halwes, C Vidler, LC Aguilar, F Taromian, DR Nisbet, M Stamp, KS Lim, AJ O'Connor, DJ Collins

2025-09-18

Pores within hydrogel structures play a crucial role in fostering cell growth and tissue development. The creation and control of ..

The Challenges and Opportunities of Protein Coronas for Nanoscale Biomolecular Sensing

S Cheeseman, P Moazzam, N Mahmoudi, M Mahmoudi, F Caruso, A Tricoli, DR Nisbet

2025-07-26

The unique benefits of sub-picomolar and single-molecule detection for the diagnosis and prognosis of diseases and therapeutic eff..

A Comprehensive Review of the Pathophysiology of Neonatal Stroke and a Critique of Current and Future Therapeutic Strategies

V Mondal, E Ross-Munro, GK Balasuriya, R Kumari, MM Hossen, M Ageeli, K Firipis, DR Nisbet, GF King, RJ Williams, P Gressens, JLY Cheong, FY Wong, DW Walker, M Tolcos, B Fleiss

2025-06-01

Within the first 28 days after birth, more than 1 in every 2500 newborns will suffer a stroke. The weekly-adjusted risk of stroke ..

Gelation Dynamics, Formation Mechanism, Functionalization, and 3D Bioprinting of Silk Fibroin Hydrogel Materials for Biomedical Applications

L Fan, Z Cai, J Zhao, N Mahmoudi, Y Wang, S Cheeseman, LC Aguilar, RL Reis, SC Kundu, DL Kaplan, DR Nisbet, JL Li

2025-05-20

Silk fibroin (SF), derived from silk cocoon fibers (Bombyx mori), is a natural protein polymer known for its biocompatibility, bio..

Insights into the Mechanism Underpinning Composite Molecular Docking During the Self-Assembly of Fucoidan Biopolymers with Peptide Nanofibrils

R Li, MR Tai, XN Su, HW Ji, JP Chen, XF Liu, BB Song, SY Zhong, DR Nisbet, CJ Barrow, RJ Williams

2025-04-01

Composite hydrogels with improved mechanical and chemical properties can be formed by non-covalently decorating the nanofibrillar ..

Test and tune: evaluating, adjusting and optimising the stiffness of hydrogels to influence cell fate

P Yang, G Boer, F Snow, A Williamson, S Cheeseman, RM Samarasinghe, A Rifai, A Priyam, R Elnathan, R Guijt, A Quigley, R Kaspa, DR Nisbet, RJ Williams

2025-02-01

The use of bioequivalent hydrogels in tissue engineering (TE) is enabling 3D tissue-like scaffolds capable of reproducing the soph..

Controlled oxygen delivery to power tissue regeneration

E Zoneff, Y Wang, C Jackson, O Smith, S Duchi, C Onofrillo, B Farrugia, SE Moulton, R Williams, C Parish, DR Nisbet, LM Caballero-Aguilar

2024-12-01

Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutio..

Dynamic interface printing

Callum Vidler, Michael Halwes, Kirill Kolesnik, Philipp Segeritz, Matthew Mail, Anders J Barlow, Emmanuelle M Koehl, Anand Ramakrishnan, Lilith M Caballero Aguilar, David R Nisbet, Daniel J Scott, Daniel E Heath, Kenneth B Crozier, David J Collins

2024-10-31

Additive manufacturing is an expanding multidisciplinary field encompassing applications including medical devices1, aerospace com..

Engineering brain-on-a-chip platforms

B Servais, N Mahmoudi, V Gautam, W Tong, MR Ibbotson, DR Nisbet, D Collins

2024-08-01

The increasing prevalence of neurological and psychiatric diseases, such as Alzheimer disease and schizophrenia, necessitates the ..

Wired for Success: Probing the Effect of Tissue-Engineered Neural Interface Substrates on Cell Viability

ATD Nascimento, AX Mendes, S Duchi, D Duc, LC Aguilar, AF Quigley, RMI Kapsa, DR Nisbet, PR Stoddart, SM Silva, SE Moulton

2024-06-10

This study investigates the electrochemical behavior of GelMA-based hydrogels and their interactions with PC12 neural cells under ..

Integrating Graphene Oxide-Hydrogels and Electrical Stimulation for Controlled Neurotrophic Factor Encapsulation: A Promising Approach for Efficient Nerve Tissue Regeneration

Alexandre Xavier Mendes, Lilith Caballero Aguilar, Adriana Teixeira do Nascimento, Serena Duchi, Mirren Charnley, David R Nisbet, Anita F Quigley, Robert MI Kapsa, Saimon Moraes Silva, Simon E Moulton

2024-06-03

Nerve growth factor (NGF) plays a crucial role in cellular growth and neurodifferentiation. To achieve significant neuronal regene..

Sex-specific nanomedicine- and biomaterials-based therapies of chronic wounds

N Mahmoudi, DR Nisbet, I Pastar, L Gould, S Matoori, M Mahmoudi

2024-06-01

Wound healing mechanisms differ depending on the sex, particularly in chronic wounds. Therefore, sex should be considered in the d..

Calming the Nerves via the Immune Instructive Physiochemical Properties of Self-Assembling Peptide Hydrogels

Negar Mahmoudi, Elmira Mohamed, Shiva Soltani Dehnavi, Lilith Caballero Aguilar, Alan R Harvey, Clare L Parish, Richard J Williams, David R Nisbet

2024-02-01

Current therapies for the devastating damage caused by traumatic brain injuries (TBI) are limited. This is in part due to poor dru..

Metallic Gallium Droplets Exhibit Poor Antibacterial Properties

M Leong, CJ Parker, ZL Shaw, LZY Huang, DR Nisbet, T Daeneke, A Elbourne, S Cheeseman

2024-01-10

The rise of antibiotic resistance in pathogenic bacteria requires new therapeutics to be developed. Several metallic nanoparticles..

A monolithic nano-scale sensor architecture with tuneable gas diffusion for molecular fingerprinting

Alishba T John, Mahdiar Taheri, Jodie A Yuwono, Priyank Kumar, David R Nisbet, Krishnan Murugappan, Antonio Tricoli

2024-01-01

Semiconducting metal oxide (SMO) gas sensors have emerged as an invaluable technology due to their high sensitivity and ease of fa..

Breaking barriers: exploring mechanisms behind opening the blood–brain barrier

MEM Stamp, M Halwes, D Nisbet, DJ Collins

2023-12-01

The blood–brain barrier (BBB) is a selectively permeable membrane that separates the bloodstream from the brain. While useful for ..